Inhibition of Transient and Persistent Na+ Current Fractions by the New Anticonvulsant Topiramate

Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels.

David S. Ragsdale, Jancy C. McPhee, Todd Scheuer et al. · Proceedings of the National Academy of Sciences · 1996 · 504 citations

Medicine, Pharmacology, Ion Channel Biophysics +16

Properties of persistent sodium conductance and calcium conductance of layer V neurons from cat sensorimotor cortex in vitro

Carl E. Stafstrom, P. C. Schwindt, M. C. Chubb et al. · Journal of Neurophysiology · 1985 · 415 citations

Life Sciences, Neurobiology, Neuroscience +17

Synchronized excitation and inhibition driven by intrinsically bursting neurons in neocortex

Yael Amitai, Barry W. Connors · Journal of Neurophysiology · 1989 · 408 citations

Life Sciences, Neurobiology, Neuroscience +17

A voltage-dependent persistent sodium current in mammalian hippocampal neurons.

Chris French, Pankaj Sah, K. J. Buckett et al. · The Journal of General Physiology · 1990 · 367 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Topiramate enhances GABA-mediated chloride flux and GABA-evoked chloride currents in murine brain neurons and increases seizure threshold

H. Steve White, S. D. Brown, José H. Woodhead et al. · Epilepsy Research · 1997 · 358 citations

Life Sciences, Neuroscience, Pharmacology +17