Liphagal, a Selective Inhibitor of PI3 Kinase α Isolated from the Sponge <i>Aka </i><i>c</i><i>oralliphaga</i>:  Structure Elucidation and Biomimetic Synthesis

Abstract

[structure: see text] Liphagal (1), a selective inhibitor of PI3K alpha, has been isolated from the marine sponge Aka coralliphaga collected in Dominica. The "liphagane" meroterpenoid carbon skeleton of liphagal (1) is new. A biomimetic total synthesis has been used to confirm the constitution of liphagal (1) and support a proposed biogenesis.