Antimicrobial Agents and Chemotherapy · 2007 · 30 citations · 21 references
Life SciencesMicrobiologyMolecular BiologyProtein TranslationRibosomal Rna ProcessingRibosome AssemblyRibosome BiogenesisTranslation ElongationTranslation RegulationTranslational Regulation60S Ribosomal Subunit BiogenesisAntibiotic Inhibition Of TranslationCell Viability AssaysLarge Ribosomal Subunit AssemblyRibosomal Protein BiosynthesisSmall Ribosomal Subunit AssemblyTranslation Kinetics
Retapamulin inhibited protein biosynthesis and cell viability in methicillin-sensitive and methicillin-resistant Staphylococcus aureus organisms. A specific inhibitory effect on 50S ribosomal subunit formation was also found. Pulse-chase labeling experiments confirmed the specific inhibition of 50S subunit biogenesis. Turnover of 23S rRNA was found, with no effect on 16S rRNA amounts.
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