A novel human immunoglobulin Fcγ–Fcɛ bifunctional fusion protein inhibits FcɛRI-mediated degranulation

Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli.

James S. Huston, Dennis J. Levinson, M Mudgett-Hunter et al. · Proceedings of the National Academy of Sciences · 1988 · 1.6K citations · Full text

Engineering, Biochemistry, Molecular Biology +17

Augmented humoral and anaphylactic responses in FcγRII-deficient mice

Toshiyuki Takai, Masao Ono, Masaki Hikida et al. · Nature · 1996 · 828 citations

Life Sciences, Immunology, Pathology +12

Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FeγRIIB

Masao Ono, Silvia Bolland, Paul Tempst et al. · Nature · 1996 · 785 citations

Life Sciences, Biochemistry, Immunology +16

The same tyrosine-based inhibition motif, in the intra-cytoplasmic domain of FcγRIIB, regulates negatively BCR-, TCR-, and FcR-dependent cell activation

Marc Daëron, Sylvain Latour, Odile Malbec et al. · Immunity · 1995 · 454 citations · Full text

Life Sciences, Cell Biology, Immunology +16

Regulation of high-affinity IgE receptor-mediated mast cell activation by murine low-affinity IgG receptors.

Marc Daëron, Odile Malbec, Sylvain Latour et al. · Journal of Clinical Investigation · 1995 · 360 citations · Full text

Life Sciences, Immunology, Molecular Biology +17