Concepedia

Degranulation Mechanisms

Degranulation Mechanism is a biological process in the context of Type I Hypersensitivity wherein activated mast cells or basophils release preformed inflammatory mediators from intracellular granules through exocytosis, initiating immediate allergic responses.

1.1K

Publications

55.8K

Citations

5.2K

Authors

1.3K

Institutions

Publications per year

2017–2026

177

Parents

Publications

1.1K

Human basophil degranulation triggered by very dilute antiserum against IgE

E. Davenas, Francis Beauvais, John P. Amara et al. · Nature · 1988 · 602 citations

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Gelatinase B functions as regulator and effector in leukocyte biology

Ghislain Opdenakker, Philippe E. Van den Steen, Bénédicte Dubois et al. · Journal of Leukocyte Biology · 2001 · 554 citations · Full text

, , +17

MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets

Ayako Kurioka, James E. Ussher, Cormac Cosgrove et al. · Mucosal Immunology · 2014 · 401 citations · Full text

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Different activation signals induce distinct mast cell degranulation strategies

Nicolas Gaudenzio, Riccardo Sibilano, Thomas Marichal et al. · Journal of Clinical Investigation · 2016 · 377 citations · Full text

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Acute Immobilization Stress Triggers Skin Mast Cell Degranulation via Corticotropin Releasing Hormone, Neurotensin, and Substance P: A Link to Neurogenic Skin Disorders

Leena K. Singh, Xinzhu Pang, Nicholas Alexacos et al. · Brain Behavior and Immunity · 1999 · 348 citations

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1–5 of 1.1K

Authors

5.2K

  1. AM
    Ann M. Dvořàk

    Harvard University, United States

    19 publications · 908 citations

    15

    h-index

  2. BB
    Barbara Baird

    Cornell University, United States

    14 publications · 711 citations

    14

    h-index

  3. DH
    David Holowka

    Cornell University, United States

    14 publications · 711 citations

    14

    h-index

  4. HA
    Hydar Ali

    University of Pennsylvania, United States

    11 publications · 809 citations

    11

    h-index

  5. DD
    Dean D. Metcalfe

    National Institute of Allergy and Infectious Diseases, United States

    10 publications · 926 citations

    10

    h-index

1–5 of 5.2K

Institutions

1.3K

  1. National Institutes of Health

    Bethesda, United States

    25 h-index

    103 publications

    6.8K citations

  2. Inserm

    Paris, France

    22 h-index

    184 publications

    15.8K citations

  3. National Institute of Allergy and Infectious Diseases

    Bethesda, United States

    19 h-index

    74 publications

    7.5K citations

  4. Harvard University

    Cambridge, United States

    19 h-index

    65 publications

    3.9K citations

  5. University of Pennsylvania

    Philadelphia, United States

    17 h-index

    72 publications

    6K citations

  6. Cornell University

    Ithaca, United States

    16 h-index

    57 publications

    2.5K citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    15 h-index

    65 publications

    2.8K citations

  8. University of Alberta

    Edmonton, Canada

    15 h-index

    65 publications

    2.3K citations

1–8 of 1.3K

Venues

  1. The Journal of Immunology

    JI · 99 publications · 7K citations

    52

    h-index

  2. PubMed

    Repository · 75 publications · 2.9K citations

    33

    h-index

  3. Journal of Biological Chemistry

    JBC · 29 publications · 2K citations

    25

    h-index

  4. Journal of Leukocyte Biology

    JLB · 25 publications · 1.5K citations

    19

    h-index

  5. PLoS ONE

    25 publications · 993 citations

    18

    h-index

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