Angewandte Chemie International Edition · 2004 · 93 citations · 19 references
Natural SciencesBiochemistryChemistryBiocatalysisEnzymologyOrganic ChemistryHeterocycle SynthesisHeterocyclic ChemistryMacrocycle SynthesisOrganic SynthesisNatural Product Total SynthesisThioketal ChemistryTotal Synthesis-derived Analogues
The flagship of the thiopeptide class of antibiotics, thiostrepton (see formula), was synthesized by fusion of the quinaldic acid moiety onto the dehydropiperidine–thiazoline macrocycle (see above) followed by demasking of its sensitive functionalities.
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Total Synthesis of Swinholide A, Preswinholide A, and Hemiswinholide A
K. C. Nicolaou, Andrew Patron, Katsuhiro Ajito et al. · Chemistry - A European Journal · 1996 · 108 citations