Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

Alan D. Irvine, Ana Terron-Kwiatkowski, Yiwei Zhao, +22

Nature Genetics

Major Predisposing FactorCommon Loss-of-function VariantsAtopic DermatitisCutaneous BiologyImmunology +6

Atopic Dermatitis

Thomas Bieber

New England Journal of Medicine

InflammationClinical ImplicationsAllergyAtopic DermatitisImmune Cell Development +11

Cytokine modulation of atopic dermatitis filaggrin skin expression

Michael Howell, Byung Eui Kim, Peisong Gao, +7

Journal of Allergy and Clinical Immunology

InflammationAutoimmune DiseaseAtopic DermatitisSkin AllergyAutoimmunity +3

Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris

Frances J.D. Smith, Alan D. Irvine, Ana Terron-Kwiatkowski, +17

Nature Genetics

BiologyMendelian DisorderGenetic DisorderGeneticsPathogenesis +8

IL-22 Inhibits Epidermal Differentiation and Induces Proinflammatory Gene Expression and Migration of Human Keratinocytes

Katia Boniface, François‐Xavier Bernard, Martine Garcia, +3

The Journal of Immunology

InflammationCytokineAutoimmune DiseaseCutaneous BiologyImmunology +12

Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways

Kristine Nograles, Lisa C. Zaba, Emma Guttman‐Yassky, +12

British Journal of Dermatology

Tight junction defects in patients with atopic dermatitis

Anna De Benedetto, Nicholas Rafaels, Laura Y. McGirt, +18

Journal of Allergy and Clinical Immunology

Atopic DermatitisTight Junction DefectsSkin AllergyContact DermatitisDermatology

Th2 Cytokines and Atopic Dermatitis

Eric B. Brandt

Journal of Clinical & Cellular Immunology

InflammationCytokineTh2 CellsAllergyAutoimmune Disease +11

Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6

Byung Eui Kim, Donald Y.M. Leung, Mark Boguniewicz, +1

Clinical Immunology

InflammationCytokineSignal TransductionAutoimmune DiseaseMedicine +11

Cytokine modulation of atopic dermatitis filaggrin skin expression

Michael Howell, Byung Eui Kim, Peisong Gao, +7

Journal of Allergy and Clinical Immunology

InflammationAutoimmune DiseaseAtopic DermatitisSkin AllergyAutoimmunity +3