Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

Alan D. Irvine, Ana Terron-Kwiatkowski, Yiwei Zhao et al. · Nature Genetics · 2006 · 2.9K citations

Major Predisposing Factor, Common Loss-of-function Variants, Atopic Dermatitis +8

Atopic Dermatitis

Thomas Bieber · New England Journal of Medicine · 2008 · 1.7K citations

Inflammation, Clinical Implications, Allergy +13

Cytokine modulation of atopic dermatitis filaggrin skin expression

Michael Howell, Byung Eui Kim, Peisong Gao et al. · Journal of Allergy and Clinical Immunology · 2007 · 1.1K citations · Full text

Inflammation, Autoimmune Disease, Atopic Dermatitis +5

Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris

Frances J.D. Smith, Alan D. Irvine, Ana Terron-Kwiatkowski et al. · Nature Genetics · 2006 · 1K citations

Biology, Mendelian Disorder, Genetic Disorder +10

IL-22 Inhibits Epidermal Differentiation and Induces Proinflammatory Gene Expression and Migration of Human Keratinocytes

Katia Boniface, François‐Xavier Bernard, Martine Garcia et al. · The Journal of Immunology · 2005 · 838 citations · Full text

Inflammation, Cytokine, Autoimmune Disease +14