Concepedia

Microreactor-based reaction optimization in organic chemistry—glycosylation as a challenge

Daniel M. Ratner, Edward R. Murphy, Manish Jhunjhunwala, Daniel A. Snyder, Klavs F. Jensen, Peter H. Seeberger

Chemical Communications · 2004 · 178 citations · 12 references

Concepts

EngineeringChemical EngineeringChemistryMicrofabricationReaction EngineeringGlycosylation PathwaysHigh-throughput SynthesisProtein GlycosylationGlycosylation Cascade ReactionsGlycosylation Method DevelopmentGlycosylation Reaction OptimizationGlycosylation Reagent DevelopmentMicroreactor DesignMicroreactor TechnologyMicroreactorsMicroscale Reaction Screening

Abstract

Glycosylation reactions are performed rapidly over a wide range of conditions as an example of microreactor-based method optimization and process development in organic chemistry.

References

12

Chemistry in Microstructured Reactors

Klaus Jähnisch, Volker Hessel, Holger Löwe et al. · Angewandte Chemie International Edition · 2004 · 1.3K citations

Engineering, Chemical Engineering, Chemistry +12

Microreaction engineering — is small better?

Klavs F. Jensen · Chemical Engineering Science · 2001 · 1.1K citations

Engineering, Mechanical Engineering, Microelectromechanical Systems +10

Micro reactors: principles and applications in organic synthesis

Paul D. I. Fletcher, Stephen J. Haswell, Esteban Pombo‐Villar et al. · Tetrahedron · 2002 · 465 citations · Full text

Engineering, Chemical Engineering, Chemistry +14

Design and fabrication of microfluidic devices for multiphase mixing and reaction

Matthew W. Losey, Rebecca J. Jackman, Samara L. Firebaugh et al. · Journal of Microelectromechanical Systems · 2002 · 232 citations

Engineering, Chemical Engineering, Materials Engineering +17

Microfluidic systems with on-line UV detection fabricated in photodefinable epoxy

Rebecca J. Jackman, Tamara M. Floyd, Reza Ghodssi et al. · Journal of Micromechanics and Microengineering · 2001 · 215 citations

Engineering, Materials Engineering, Materials Science +15