Biology Open · 2015 · 19 citations · 41 references
Life SciencesCell BiologyDevelopmental BiologyCell DivisionCellular NeuroscienceDevelopmental NeuroscienceCerebellar DevelopmentHedgehog SignalingNeural DevelopmentNeurogenesisNeuronal DevelopmentNeuronal DifferentiationCell Division ControlCerebellar MorphogenesisCerebellar NeurogenesisGranule Cell LayerMorphogen Signaling In Neural DevelopmentNeural Stem Cell Asymmetric DivisionNeuronal MorphogenesisPial Surface Anatomy
The plane of division of granule neuron progenitors (GNPs) was analysed with respect to the pial surface in P0 to P14 cerebellum and the results showed that there was a significant bias towards the plane of cell division being parallel to pial surface across this developmental window. In addition, the distribution of β-Catenin in anaphase cells was analysed, which showed that there was a significant asymmetry in the distribution of β-Catenin in dividing GNPs. Further, inhibition of Sonic Hedgehog (Shh) signalling had an effect on plane of cell division. Asymmetric distribution of β-Catenin was shown to occur towards the source of a localized extracellular cue.
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Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
James Chen, Jussi Taipale, Michael K. Cooper et al. · Genes & Development · 2002 · 1.5K citations · Full text