The Journal of Infectious Diseases · 2009 · 38 citations · 14 references
Life SciencesImmunologyInfectious DiseasesCellular ImmunologyClinical ImmunologyImmunoregulationCell-mediated ImmunityCellular Immunity In InfectionImmunodeficiency DisordersRegulatory T CellsT Cell ActivationT Cell BiologyCd4 Positive T CellsCell ActivationHiv-associated ImmunosuppressionPeripheral Regulatory T CellsT-cell Immune ResponsesT-cell Immunophenotypes
The most commonly used regulatory T cell (Treg) phenotypes, CD4(+)CD25(hi)CD127(lo) and CD4(+)CD25(hi)FoxP3(+), were simultaneously used to determine the Treg frequency in 2 different groups of human immunodeficiency virus (HIV)-infected persons, one viremic and other aviremic. As expected, a strong correlation between both Treg phenotypes was observed in the aviremic group (r = 0.913; P < .001), but surprisingly, this correlation was completely absent in the viremic group (r = 0.143; P = .572). Data on T cell activation levels of both HIV groups suggest that the CD4(+)CD25(hi)CD127(lo) phenotype could just be mirroring the elevated numbers of activated non-regulatory T cells in the viremic HIV group.
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