Identification of a Functional Antioxidant Response Element within the Eighth Intron of the Human ABCC3 Gene

Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

Donna D. Zhang, Mark Hannink · Molecular and Cellular Biology · 2003 · 1.4K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +13

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

Deepti Malhotra, Élodie Portales-Casamar, Anju Singh et al. · Nucleic Acids Research · 2010 · 781 citations · Full text

Life Sciences, Cell Biology, Molecular Genetics +17

The Cytochrome P450 2B6 (CYP2B6) Is the Main Catalyst of Efavirenz Primary and Secondary Metabolism: Implication for HIV/AIDS Therapy and Utility of Efavirenz as a Substrate Marker of CYP2B6 Catalytic Activity

Bryan A. Ward, J. Christopher Gorski, David R. Jones et al. · Journal of Pharmacology and Experimental Therapeutics · 2003 · 594 citations

Medicine, Pharmacokinetics, Pharmacology +17

Validation of Bupropion Hydroxylation as a Selective Marker of Human Cytochrome P450 2B6 Catalytic Activity

Stephanie Faucette, Roy L. Hawke, Edward L. LeCluyse et al. · Drug Metabolism and Disposition · 2000 · 356 citations

Medicine, Biochemistry, Pharmacology +17

Oxidative and electrophilic stress induces multidrug resistance–associated protein transporters via the nuclear factor-E2–related factor-2 transcriptional pathway

Jonathan Maher, Matthew Z. Dieter, Lauren M. Aleksunes et al. · Hepatology · 2007 · 312 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17