HDAC inhibitor sodium butyrate reverses transcriptional downregulation and ameliorates ataxic symptoms in a transgenic mouse model of SCA3

CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1

Yoshiya Kawaguchi, Toshihiro Okamoto, Masafumi Taniwaki et al. · Nature Genetics · 1994 · 1.8K citations

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Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

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Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

Ruth Luthi‐Carter · Human Molecular Genetics · 2000 · 722 citations

Life Sciences, Genetics, Neuroscience +15

Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice

Robert J. Ferrante, James K. Kubilus, Junghee Lee et al. · Journal of Neuroscience · 2003 · 689 citations · Full text

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Mapping Global Histone Acetylation Patterns to Gene Expression

Siavash K. Kurdistani, Saeed Tavazoie, Michael Grunstein · Cell · 2004 · 639 citations · Full text

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