Polyglutamine-expanded ataxin-3 causes cerebellar dysfunction of SCA3 transgenic mice by inducing transcriptional dysregulation

An-Hsun Chou, Tu‐Hsueh Yeh, Pin Ouyang, +3

Neurobiology of Disease

Knockout MouseNeurodegenerative DiseasesSca3 Transgenic MiceMolecular NeuroscienceDevelopmental Biology +6

PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons

Hung‐Li Wang, An-Hsun Chou, Ai-Shun Wu, +6

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

MitophagyMitochondrial FunctionDopaminergic NeuronsMitochondrial MedicineNeuroscience +4

Polyglutamine-expanded ataxin-3 activates mitochondrial apoptotic pathway by upregulating Bax and downregulating Bcl-xL

An-Hsun Chou, Tu‐Hsueh Yeh, Yu-Li Kuo, +6

Neurobiology of Disease

Signal TransductionMitochondrial FunctionApoptosisImmunologyCell Death +4

HDAC inhibitor sodium butyrate reverses transcriptional downregulation and ameliorates ataxic symptoms in a transgenic mouse model of SCA3

An-Hsun Chou, Si-Ying Chen, Tu‐Hsueh Yeh, +2

Neurobiology of Disease

Transcriptional DownregulationKnockout MouseTranscriptional RegulationOncogenic AgentGenetics +7

PINK1 mutants associated with recessive Parkinson’s disease are defective in inhibiting mitochondrial release of cytochrome c

Hung‐Li Wang, An-Hsun Chou, Tu‐Hsueh Yeh, +5

Neurobiology of Disease

Mitochondrial ReleaseNeurodegenerative DiseasesBiochemistryMitochondrial FunctionPink1 Mutants +6

An Analysis of Perioperative Eye Injuries After Nonocular Surgery

Han-Dung Yu, An-Hsun Chou, Min-Wen Yang, +1

Acta anaesthesiologica Taiwanica

Ophthalmic SurgeryOphthalmologyOculoplasticsNonocular SurgeryPerioperative Safety +4

Polyglutamine-expanded ataxin-7 activates mitochondrial apoptotic pathway of cerebellar neurons by upregulating Bax and downregulating Bcl-xL

Hung‐Li Wang, Tu‐Hsueh Yeh, An-Hsun Chou, +4

Cellular Signalling

MitophagyMolecular NeuroscienceSignal TransductionMitochondrial FunctionMitochondrial Dynamic +8

H1152 promotes the degradation of polyglutamine-expanded ataxin-3 or ataxin-7 independently of its ROCK-inhibiting effect and ameliorates mutant ataxin-3-induced neurodegeneration in the SCA3 transgenic mouse

Hung‐Li Wang, Su-Huei Hu, An-Hsun Chou, +3

Neuropharmacology

Knockout MouseNeurodegenerative DiseasesMolecular NeuroscienceDevelopmental BiologyAutophagy +11

Polyglutamine-expanded ataxin-7 upregulates Bax expression by activating p53 in cerebellar and inferior olivary neurons

Hung‐Li Wang, An-Hsun Chou, An-Chi Lin, +3

Experimental Neurology

Molecular NeuroscienceSignal TransductionCell DeathInferior Olivary NeuronsNeuroprotection +8

T1-11 and JMF1907 ameliorate polyglutamine-expanded ataxin-3-induced neurodegeneration, transcriptional dysregulation and ataxic symptom in the SCA3 transgenic mouse

An-Hsun Chou, Ying‐Ling Chen, Ching‐Chi Chiu, +6

Neuropharmacology

Knockout MouseNeurodegenerative DiseasesAtaxic SymptomAutoimmune DiseaseMedicine +8