Maternal B vitamin supplementation from preconception through weaning suppresses intestinal tumorigenesis in Apc^1638N mouse offspring

Abstract

These changes indicate a de-repression of the Wnt pathway in pups of deficient dams and form a plausible mechanism by which maternal B vitamin intake modulates tumorigenesis in offspring. These data indicate that maternal B vitamin supplementation suppresses, while deficiency promotes, intestinal tumorigenesis in Apc(1638N) offspring.