Computational Discovery of Novel Low Micromolar Human Pregnane X Receptor Antagonists

Development and validation of a genetic algorithm for flexible docking 1 1Edited by F. E. Cohen

Gareth Jones, Peter Willett, Robert C. Glen et al. · Journal of Molecular Biology · 1997 · 6.7K citations

Pharmacy, Bioinformatics, Medicinal Chemistry +14

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

Steven A. Kliewer, John T. Moore, Laura Wade et al. · Cell · 1998 · 1.5K citations · Full text

Life Sciences, Biochemistry, Endocrinology +16

SXR, a novel steroid and xenobioticsensing nuclear receptor

Bruce Blumberg, Walid Sabbagh, Henry Juguilon et al. · Genes & Development · 1998 · 920 citations · Full text

Life Sciences, Endocrinology, Molecular Biology +17

Identification of a human nuclear receptor defines a new signaling pathway for <i>CYP</i> <i>3</i> A induction

Göran Bertilsson, Jessica Heidrich, Kristian Svensson et al. · Proceedings of the National Academy of Sciences · 1998 · 871 citations · Full text

Medicine, Molecular Biology, Pharmacology +15

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

Timothy W. Synold, Isabelle Dussault, Barry M. Forman · Nature Medicine · 2001 · 834 citations

Medicine, Molecular Biology, Pharmacology +11