Concepedia

An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity

Tom J. Petty, Soheila Emamzadah, Lorenzo Costantino, Irina Petkova, Elena S. Stavridi, Jeffery G. Saven, Eric Vauthey, Thanos D. Halazonetis

The EMBO Journal · 2011 · 113 citations · 46 references

DOIFull text

Open access

Concepts

References

46

Surfing the p53 network

Bert Vogelstein, David P. Lane, Arnold J. Levine · Nature · 2000 · 6.6K citations

, , +6

Participation of p53 protein in the cellular response to DNA damage.

Michael B. Kastan, Onyinye Onyekwere, D Sidransky et al. · PubMed · 1991 · 3.8K citations

, , +14

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

Jiřina Bártková, Zuzana Hořejšı́, Karen Koed et al. · Nature · 2005 · 2.7K citations

, , +16

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

Yunje Cho, Svetlana S. Gorina, Philip D. Jeffrey et al. · Science · 1994 · 2.5K citations

, , +16

Application of a Theory of Enzyme Specificity to Protein Synthesis

Daniel E. Koshland · Proceedings of the National Academy of Sciences · 1958 · 2.4K citations · Full text

, , +14