Human Engineered Heart Muscles Engraft and Survive Long Term in a Rodent Myocardial Infarction Model

Abstract

EHM transplantation led to high engraftment rates, long-term survival, and progressive maturation of human cardiomyocytes. However, cell engraftment was not correlated with functional improvements in this chronic myocardial infarction model. Most importantly, the safety of this approach was demonstrated by the lack of tumor or teratoma formation.