Usefulness of one-point plasma SN-38G/SN-38 concentration ratios as a substitute for UGT1A1 genetic information after irinotecan administration

Genetic Variants in the <i>UDP-glucuronosyltransferase 1A1</i> Gene Predict the Risk of Severe Neutropenia of Irinotecan

Federico Innocenti, Samir D. Undevia, Lalitha Iyer et al. · Journal of Clinical Oncology · 2004 · 954 citations · Full text

Medicine, Oncology, Pharmacology +17

Polymorphisms of UDP-glucuronosyltransferase gene and irinotecan toxicity: a pharmacogenetic analysis.

Yukio Ando, Hideo Saka, Maki Ando et al. · PubMed · 2000 · 788 citations

Medicine, Genetics, Pharmacology +15

Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: roles of UGT1A1*6 and *28

Hironobu Minami, Kimie Sai, Mayumi Saeki et al. · Pharmacogenetics and Genomics · 2007 · 288 citations

Medicine, Pharmacokinetics, Pharmacology +17

UGT1A1 haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese patients with cancer*1

Katsunari Sai · Clinical Pharmacology & Therapeutics · 2004 · 260 citations

Medicine, Genetics, Oncology +15

UGT1A1*6 polymorphism is most predictive of severe neutropenia induced by irinotecan in Japanese cancer patients

Masahide Onoue, Tomohiro Terada, Masahiko Kobayashi et al. · International Journal of Clinical Oncology · 2009 · 101 citations

Medicine, Genetics, Oncology +11