Novel orally active inhibitors of β-1,3-glucan synthesis derived from enfumafungin

Discovery of Novel Antifungal (1,3)-β- <scp>d</scp> -Glucan Synthase Inhibitors

Janet C. Onishi, M. Meinz, John R. Thompson et al. · Antimicrobial Agents and Chemotherapy · 2000 · 313 citations · Full text

Medicinal Chemistry, Biosynthesis, Antimicrobial Drug Discovery +15

Evaluation of the echinocandin antifungal MK-0991 (L-743,872): efficacies in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis

George K. Abruzzo, Amy Flattery, Christopher Gill et al. · Antimicrobial Agents and Chemotherapy · 1997 · 244 citations · Full text

The Discovery of Enfumafungin, a Novel Antifungal Compound Produced by an Endophytic Hormonema Species Biological Activity and Taxonomy of the Producing Organisms

Fernando Peláez, Angeles Cabello, Gonzalo Platas et al. · Systematic and Applied Microbiology · 2000 · 149 citations

Biosynthesis, Antifungal Agent, Antifungal Agents +7

In vitro antifungal activities and in vivo efficacies of 1,3-beta-D-glucan synthesis inhibitors L-671,329, L-646,991, tetrahydroechinocandin B, and L-687,781, a papulacandin

Ken Bartizal, George K. Abruzzo, Charlotte Trainor et al. · Antimicrobial Agents and Chemotherapy · 1992 · 93 citations

Vitro Antifungal Activities, Antifungal Agent, Tetrahydroechinocandin B +14

Discovery of a Novel Class of Orally Active Antifungal β-1,3- <scp>d</scp> -Glucan Synthase Inhibitors

Scott S. Walker, Yiming Xu, Ilias Triantafyllou et al. · Antimicrobial Agents and Chemotherapy · 2011 · 75 citations · Full text

Medicinal Chemistry, Antifungal Agent, Biochemistry +11