Concepedia

Subvisible Particle Counting Provides a Sensitive Method of Detecting and Quantifying Aggregation of Monoclonal Antibody Caused by Freeze-Thawing: Insights Into the Roles of Particles in the Protein Aggregation Pathway

James G. Barnard, Satish Kumar Singh, Theodore W. Randolph, John F. Carpenter

Journal of Pharmaceutical Sciences · 2010 · 150 citations · 15 references

Open access

References

15

Overlooking Subvisible Particles in Therapeutic Protein Products: Gaps That May Compromise Product Quality

John F. Carpenter, Theodore W. Randolph, Wim Jiskoot et al. · Journal of Pharmaceutical Sciences · 2008 · 588 citations · Full text

Life Sciences, Biochemistry, Pharmaceutics +16

Kinetics of insulin aggregation in aqueous solutions upon agitation in the presence of hydrophobic surfaces.

Victoria Sluzky, J A Tamada, Alexander M. Klibanov et al. · Proceedings of the National Academy of Sciences · 1991 · 518 citations

Natural Sciences, Biochemistry, Chemistry +15

Surface-Induced Denaturation of Proteins during Freezing and its Inhibition by Surfactants

Byeong S. Chang, Brent S. Kendrick, John F. Carpenter · Journal of Pharmaceutical Sciences · 1996 · 472 citations

Life Sciences, Biochemistry, Protein Biochemistry +11

Shaken, Not Stirred: Mechanical Stress Testing of an IgG1 Antibody

Sylvia Kiese, Astrid Papppenberger, Hanns‐Christian Mahler · Journal of Pharmaceutical Sciences · 2008 · 397 citations

Pharmacy, Immunology, Molecular Biology +6

Effects of Tween 20® and Tween 80® on the Stability of Albutropin During Agitation

Danny K. Chou, Rajesh Krishnamurthy, Theodore W. Randolph et al. · Journal of Pharmaceutical Sciences · 2005 · 306 citations

Pharmacy, Pharmaceutics, Bioavailability +5