Microsatellite Instability, Mismatch Repair Deficiency, and <i>BRAF</i> Mutation in Treatment-Resistant Germ Cell Tumors

Abstract

We report for the first time a correlation between a gene mutation--BRAF V600E--and cisplatin resistance in nonseminomatous GCTs. Furthermore, a correlation between MMR deficiency, MSI, and treatment failure is confirmed.