Pharmacological Characterization of Olodaterol, a Novel Inhaled β2-Adrenoceptor Agonist Exerting a 24-Hour-Long Duration of Action in Preclinical Models

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

Global strategy for asthma management and prevention: GINA executive summary

Eric D. Bateman, Suzanne S. Hurd, Peter J. Barnes et al. · European Respiratory Journal · 2007 · 3.2K citations · Full text

Public Affairs, Health Policy, Global Health +6

A 4-Year Trial of Tiotropium in Chronic Obstructive Pulmonary Disease

Donald P. Tashkin, Bartolomé R. Celli, Stephen Senn et al. · New England Journal of Medicine · 2008 · 2.2K citations · Full text

Pharmacy, Clinical Sciences, Pharmacotherapy +17

Efficacy of salmeterol/fluticasone propionate by GOLD stage of chronic obstructive pulmonary disease: analysis from the randomised, placebo-controlled TORCH study

Christine Jenkins, Paul Jones, Peter M.A. Calverley et al. · Respiratory Research · 2009 · 344 citations · Full text

Medicine, Pharmacotherapy, Pulmonary Function Testing +16

Preclinical Evaluation of Long-Acting Muscarinic Antagonists: Comparison of Tiotropium and Investigational Drugs

Paola Casarosa, Thierry Bouyssou, Sabine Germeyer et al. · Journal of Pharmacology and Experimental Therapeutics · 2009 · 141 citations

Medicine, Pharmacology, Pharmacotherapy +17