Concepedia

Pharmacodynamic Selectivity

Pharmacodynamic Selectivity is a pharmacological property that refers to the preferential interaction of a drug with specific molecular targets or tissue-based physiological pathways, thereby producing distinct therapeutic effects relative to off-target or non-selective actions within the body.

74

Publications

6.1K

Citations

616

Authors

121

Institutions

Publications per year

2017–2026

16

Parents

Publications

74

Synergistic drug combinations tend to improve therapeutically relevant selectivity

Joseph Lehár, Andrew Krueger, William Avery et al. · Nature Biotechnology · 2009 · 957 citations · Full text

, , +13

Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: Results from two randomized, double-blind, placebo-controlled studies with single oral doses

Gary Herman, C. Melinda Stevens, Koen Vandyck et al. · Clinical Pharmacology & Therapeutics · 2005 · 519 citations

, , +14

AZD4547: An Orally Bioavailable, Potent, and Selective Inhibitor of the Fibroblast Growth Factor Receptor Tyrosine Kinase Family

Paul R. Gavine, Lorraine Mooney, Elaine Kilgour et al. · Cancer Research · 2012 · 499 citations

, , +16

Discovery and Pharmacological Characterization of JNJ-42756493 (Erdafitinib), a Functionally Selective Small-Molecule FGFR Family Inhibitor

Timothy Perera, Eleonora Jovcheva, Laurence Mévellec et al. · Molecular Cancer Therapeutics · 2017 · 340 citations · Full text

, , +17

Pharmacokinetic and pharmacodynamic actions of clozapine-N-oxide, clozapine, and compound 21 in DREADD-based chemogenetics in mice

Martin M. Jendryka, Monika Palchaudhuri, Daniel Ursu et al. · Scientific Reports · 2019 · 323 citations · Full text

, , +15

1–5 of 74

Authors

616

  1. LX
    Liang Xie

    Sichuan University, China

    2 publications · 495 citations

    2

    h-index

  2. CR
    Carlotta Ronchi

    University of Milano-Bicocca, Italy

    2 publications · 33 citations

    2

    h-index

  3. AZ
    Antonio Zaza

    University of Milano-Bicocca, Italy

    2 publications · 33 citations

    2

    h-index

  4. FP
    Francesco Peri

    University of Milano-Bicocca, Italy

    2 publications · 33 citations

    2

    h-index

  5. MA
    Martina Arici

    University of Milano-Bicocca, Italy

    2 publications · 33 citations

    2

    h-index

1–5 of 616

Institutions

121

  1. AstraZeneca (United Kingdom)

    Cambridge, United Kingdom

    3 h-index

    41 publications

    10.1K citations

  2. National Institutes of Health

    Bethesda, United States

    2 h-index

    4 publications

    558 citations

  3. Tufts Medical Center

    Boston, United States

    2 h-index

    8 publications

    341 citations

  4. University of Milano-Bicocca

    Milan, Italy

    2 h-index

    19 publications

    346 citations

  5. Tufts University

    Medford, United States

    2 h-index

    2 publications

    137 citations

  6. Windtree Therapeutics (United States)

    Philadelphia, United States

    2 h-index

    6 publications

    99 citations

  7. Boehringer Ingelheim (Germany)

    Ingelheim, Germany

    2 h-index

    12 publications

    2.4K citations

  8. Northeastern University

    Boston, United States

    2 h-index

    2 publications

    90 citations

1–8 of 121

Venues

  1. 7

    h-index

  2. PubMed

    Repository · 6 publications · 162 citations

    6

    h-index

  3. Journal of Medicinal Chemistry

    5 publications · 392 citations

    5

    h-index

  4. European Journal of Pharmacology

    EJP · 3 publications · 43 citations

    3

    h-index

  5. Structure

    2 publications · 120 citations

    2

    h-index

1–5