Concepedia

Design and evaluation of 3,6-di(hetero)aryl imidazo[1,2-a]pyrazines as inhibitors of checkpoint and other kinases

Thomas P. Matthews, Tatiana McHardy, Suki Klair, Kathy Boxall, Martin Fisher, Michael Cherry, Charlotte E. Allen, Glynn Addison, John Ellard, G. Wynne Aherne,

Bioorganic & Medicinal Chemistry Letters · 2010 · 29 citations · 9 references

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9

Heteroaromatic Rings of the Future

William R. Pitt, David M. Parry, Benjamin Perry et al. · Journal of Medicinal Chemistry · 2009 · 336 citations

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Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1

Alessandra Blasina, Jill Hallin, Enhong Chen et al. · Molecular Cancer Therapeutics · 2008 · 226 citations · Full text

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Measuring and interpreting the selectivity of protein kinase inhibitors

Lynette A. Smyth, Ian Collins · Journal of Chemical Biology · 2009 · 191 citations · Full text

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The Preclinical Pharmacology and Therapeutic Activity of the Novel CHK1 Inhibitor SAR-020106

Michael I. Walton, Paul D. Eve, Angela Hayes et al. · Molecular Cancer Therapeutics · 2010 · 101 citations · Full text

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Inhibitors of checkpoint kinases: from discovery to the clinic.

James W. Janetka, Susan Ashwell, Sonya Zabludoff et al. · PubMed · 2007 · 65 citations

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