Induction of Cytochrome P450 3A4 in Primary Human Hepatocytes and Activation of the Human Pregnane X Receptor by Tamoxifen and 4-Hydroxytamoxifen

Genomic sequencing.

George M. Church, W Gilbert · Proceedings of the National Academy of Sciences · 1984 · 8.2K citations · Full text

Life Sciences, Genetics, Molecular Biology +12

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

J�rgen Lehmann, David D. McKee, M. A. Watson et al. · Journal of Clinical Investigation · 1998 · 1.6K citations · Full text

Medicine, Molecular Biology, Pharmacology +14

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

Linda B. Moore, Bryan Goodwin, Stacey A. Jones et al. · Proceedings of the National Academy of Sciences · 2000 · 938 citations

Medicine, Pharmacology, Toxicology +17

SXR, a novel steroid and xenobioticsensing nuclear receptor

Bruce Blumberg, Walid Sabbagh, Henry Juguilon et al. · Genes & Development · 1998 · 920 citations · Full text

Life Sciences, Endocrinology, Molecular Biology +17

Identification of a human nuclear receptor defines a new signaling pathway for <i>CYP</i> <i>3</i> A induction

Göran Bertilsson, Jessica Heidrich, Kristian Svensson et al. · Proceedings of the National Academy of Sciences · 1998 · 871 citations · Full text

Medicine, Molecular Biology, Pharmacology +15