Concepedia

Two‐ to three‐fold increase in blood tacrolimus (FK506) levels during diarrhea in liver‐transplanted children

J. Iglesias Berengué, Jesús Alberto López‐Espinosa, Juan Ortega‐López, Luz María Sánchez‐Sánchez, Patricia Castilla‐Valdes, Marino Asensio‐Llorente, Carlos Margarit‐Creixell

Clinical Transplantation · 2003 · 20 citations · 25 references

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Abstract

Until the role played by the intestine in the metabolism of tacrolimus is fully understood, it is prudent to recommend early dose reduction of tacrolimus and careful monitoring of trough levels during diarrheal disorders of any nature in pediatric liver-transplanted patients.

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