Concepedia

Trough Concentrations

Trough Concentrations is the lowest concentration of a drug in the bloodstream, measured immediately before the next scheduled dose in a multiple-dose pharmacokinetic regimen, that serves as a critical indicator for maintaining therapeutic efficacy within the therapeutic window.

1.3K

Publications

62.5K

Citations

7.5K

Authors

1.9K

Institutions

Publications per year

2017–2026

288

Variants

CminTrough Levels

Parents

Publications

1.3K

Trough Concentrations of Infliximab Guide Dosing for Patients With Inflammatory Bowel Disease

Niels Vande Casteele, Marc Ferrante, Gert Van Assche et al. · Gastroenterology · 2015 · 873 citations

, , +16

High-Dose Vancomycin Therapy for Methicillin-Resistant Staphylococcus aureus Infections

Levita Hidayat, Donald Hsu, Ryan Quist et al. · Archives of Internal Medicine · 2006 · 849 citations

, , +17

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for <i>CYP3A5</i> Genotype and Tacrolimus Dosing

Brian S. Decker, JM Barbarino, JF Peterson et al. · Clinical Pharmacology & Therapeutics · 2015 · 692 citations · Full text

, , +17

Effects of Ranolazine With Atenolol, Amlodipine, or Diltiazem on Exercise Tolerance and Angina Frequency in Patients With Severe Chronic Angina&lt;SUBTITLE&gt;A Randomized Controlled Trial&lt;/SUBTITLE&gt;

Bernard Chaitman · JAMA · 2004 · 676 citations

, , +17

Daily Oral Everolimus Activity in Patients With Metastatic Pancreatic Neuroendocrine Tumors After Failure of Cytotoxic Chemotherapy: A Phase II Trial

James C. Yao, Catherine Lombard‐Bohas, Éric Baudin et al. · Journal of Clinical Oncology · 2009 · 649 citations · Full text

, , +17

1–5 of 1.3K

Authors

7.5K

  1. JA
    Jason A. Roberts

    The University of Queensland, Australia

    10 publications · 999 citations

    10

    h-index

  2. MJ
    Michael J. Rybak

    Wayne State University, United States

    10 publications · 904 citations

    10

    h-index

  3. EJ
    Evan J. Begg

    Christchurch Hospital, New Zealand

    9 publications · 352 citations

    9

    h-index

  4. SV
    Séverine Vermeire

    KU Leuven, Belgium

    9 publications · 1.5K citations

    9

    h-index

  5. KM
    Karsten Midtvedt

    Oslo University Hospital, Norway

    9 publications · 399 citations

    9

    h-index

1–5 of 7.5K

Institutions

1.9K

  1. Inserm

    Paris, France

    22 h-index

    107 publications

    4.2K citations

  2. Radboud University Nijmegen

    Nijmegen, The Netherlands

    21 h-index

    88 publications

    5.3K citations

  3. Radboud University Medical Center

    Nijmegen, The Netherlands

    19 h-index

    75 publications

    5K citations

  4. Wayne State University

    Detroit, United States

    16 h-index

    44 publications

    3.6K citations

  5. The University of Queensland

    Brisbane, Australia

    16 h-index

    47 publications

    5.6K citations

  6. KU Leuven

    Leuven, Belgium

    16 h-index

    82 publications

    10.5K citations

  7. University of Minnesota

    Minneapolis, United States

    16 h-index

    60 publications

    3.4K citations

  8. University of California, San Francisco

    San Francisco, United States

    15 h-index

    55 publications

    2.7K citations

1–8 of 1.9K

Venues

  1. Antimicrobial Agents and Chemotherapy

    AAC · 100 publications · 6.4K citations

    48

    h-index

  2. Therapeutic Drug Monitoring

    78 publications · 2.9K citations

    31

    h-index

  3. British Journal of Clinical Pharmacology

    BJCP · 50 publications · 2.9K citations

    30

    h-index

  4. 28

    h-index

  5. Clinical Pharmacology & Therapeutics

    CPT · 36 publications · 4.5K citations

    28

    h-index

1–5