High-Dose Vancomycin Therapy for Methicillin-Resistant Staphylococcus aureus Infections

Abstract

High prevalence of clinical MRSA strains with elevated vancomycin MIC (2 microg/mL) requires aggressive empirical vancomycin dosing to achieve a trough greater than 15 microg/mL. Combination or alternative therapy should be considered for invasive infections caused by these strains.