Concepedia

Monoclonal Antibodies with Identical Fc Sequences Can Bind to FcRn Differentially with Pharmacokinetic Consequences

Weirong Wang, Ping Lü, Yulin Fang, Lora Hamuro, Tamara Pittman, Brian I. Carr, Jerome Hochman, Thomayant Prueksaritanont

Drug Metabolism and Disposition · 2011 · 160 citations · 28 references

DOI

Concepts

References

28

Monoclonal Antibody Pharmacokinetics and Pharmacodynamics

Wenhui Wang, EQ Wang, JP Balthasar · Clinical Pharmacology & Therapeutics · 2008 · 954 citations

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Enhanced antibody half-life improves in vivo activity

Jonathan Zalevsky, Aaron K. Chamberlain, Holly M. Horton et al. · Nature Biotechnology · 2010 · 644 citations · Full text

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The Major Histocompatibility Complex–related Fc Receptor for IgG (FcRn) Binds Albumin and Prolongs Its Lifespan

Chaity Chaudhury, Samina Mehnaz, John M. Robinson et al. · The Journal of Experimental Medicine · 2003 · 637 citations · Full text

, , +14

Properties of Human IgG1s Engineered for Enhanced Binding to the Neonatal Fc Receptor (FcRn)

William F. Dall’Acqua, Peter A. Kiener, Herren Wu · Journal of Biological Chemistry · 2006 · 637 citations · Full text

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Differences in promiscuity for antibody–FcRn interactions across species: implications for therapeutic antibodies

Raimund J. Ober, Caius G. Radu, Victor Gheţie et al. · International Immunology · 2001 · 494 citations

, , +17