Prevalence of the Alternative Lengthening of Telomeres Telomere Maintenance Mechanism in Human Cancer Subtypes

A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes.

Robert K. Moyzis, Judy M. Buckingham, L. Scott Cram et al. · Proceedings of the National Academy of Sciences · 1988 · 2.3K citations · Full text

Dna, Cytogenetics, Genetics +18

Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

Tracy M. Bryan, Anna Englezou, Luciano Dalla‐Pozza et al. · Nature Medicine · 1997 · 1.3K citations

Tumor Biology, Alternative Mechanism, Medicine +9

How Telomeres Solve the End-Protection Problem

Titia de Lange · Science · 2009 · 829 citations · Full text

Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body.

Thomas R. Yeager, Axel A. Neumann, Anna Englezou et al. · PubMed · 1999 · 691 citations

Hematological Malignancy, Chromatin, Genome Instability +13

A Robust Assay for Alternative Lengthening of Telomeres in Tumors Shows the Significance of Alternative Lengthening of Telomeres in Sarcomas and Astrocytomas

Jeremy D. Henson, Jonathan Hannay, Stanley W. McCarthy et al. · Clinical Cancer Research · 2005 · 296 citations · Full text