Rifampicin-Activated Human Pregnane X Receptor and CYP3A4 Induction Enhance Acetaminophen-Induced Toxicity

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

J�rgen Lehmann, David D. McKee, M. A. Watson et al. · Journal of Clinical Investigation · 1998 · 1.6K citations · Full text

Medicine, Molecular Biology, Pharmacology +14

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

Steven A. Kliewer, John T. Moore, Laura Wade et al. · Cell · 1998 · 1.5K citations · Full text

Life Sciences, Biochemistry, Endocrinology +16

SXR, a novel steroid and xenobioticsensing nuclear receptor

Bruce Blumberg, Walid Sabbagh, Henry Juguilon et al. · Genes & Development · 1998 · 920 citations · Full text

Life Sciences, Endocrinology, Molecular Biology +17

Large-Scale Human Metabolomics Studies:  A Strategy for Data (Pre-) Processing and Validation

Sabina Bijlsma, I. Bobeldijk, Elwin Verheij et al. · Analytical Chemistry · 2005 · 878 citations

Life Sciences, Biochemistry, Mass Spectrometric Analysis +16

Role of CYP2E1 in the Hepatotoxicity of Acetaminophen

Susanna S.T. Lee, Jeroen Buters, Thierry Pineau et al. · Journal of Biological Chemistry · 1996 · 658 citations · Full text

Medicine, Pharmacology, Toxicology +15