Cardiac-Targeted Transgenic Mutant Mitochondrial Enzymes: mtDNA Defects, Antiretroviral Toxicity and Cardiomyopathy

3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro.

Hiroaki Mitsuya, Kent J. Weinhold, P A Furman et al. · Proceedings of the National Academy of Sciences · 1985 · 1.8K citations · Full text

Immunology, Bw A509u, Cytopathic Effect +16

Mitochondrial Myopathy Caused by Long-Term Zidovudine Therapy

Marinos C. Dalakas, Isabel Illa, G. Pezeshkpour et al. · New England Journal of Medicine · 1990 · 845 citations · Full text

Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy

Ann Saada, Avraham Shaag, Hanna Mandel et al. · Nature Genetics · 2001 · 614 citations

Mitochondrial Myopathy, Mitochondrial Function, Natural Sciences +4

Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion

Alice Bourdon, Limor Minai, Valérie Serre et al. · Nature Genetics · 2007 · 517 citations

Genome Instability, Mitochondrial Function, P53-controlled Ribonucleotide Reductase +10

Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice.

A. Subramaniam, W. Keith Jones, James Gulick et al. · Journal of Biological Chemistry · 1991 · 472 citations · Full text

Transgenic Mouse Models, Molecular Regulation, Transgene Expression +18