Decreased mtDNA, oxidative stress, cardiomyopathy, and death from transgenic cardiac targeted human mutant polymerase γ

William Lewis, Brian J. Day, James J. Kohler, +12

Laboratory Investigation

CardiomyopathyTransgenic CardiacMitochondrial FunctionNatural SciencesGenetics +8

Antiretroviral nucleosides, deoxynucleotide carrier and mitochondrial DNA: evidence supporting the DNA pol γ hypothesis

William Lewis, James J. Kohler, Seyed Hamzeh Hosseini, +8

AIDS

Draft sequencing and assembly of the genome of the world’s largest fish, the whale shark: Rhincodon typus Smith 1828

Timothy D. Read, Robert A. Petit, Sandeep J. Joseph, +9

BMC Genomics

Targeted myocardial transgenic expression of HIV Tat causes cardiomyopathy and mitochondrial damage

Scott M. Raidel, Chad P. Haase, Natalie R. Jansen, +7

American Journal of Physiology-Heart and Circulatory Physiology

Cardiac MuscleCardiomyopathyHeart FailureMitochondrial DamageCardiovascular Disease +13

Combined Antiretroviral Therapy Causes Cardiomyopathy and Elevates Plasma Lactate in Transgenic AIDS Mice

William Lewis, Chad P. Haase, Scott M. Raidel, +4

Laboratory Investigation

Transgenic Aids MiceNeurovirologyHuman RetrovirusAntiviral ResponseAntiviral Therapy +5

Nucleoside reverse transcriptase inhibitors impair endothelium-dependent relaxation by increasing superoxide

Roy L. Sutliff, Sergey Dikalov, Daiana Weiss, +7

American Journal of Physiology-Heart and Circulatory Physiology

Lipid PeroxidationImmunologyPharmacotherapyCardiovascular ToxicityRedox Biology +16

Global mRNA decay analysis at single nucleotide resolution reveals segmental and positional degradation patterns in a Gram-positive bacterium

Simen M. Kristoffersen, Chad P. Haase, Michael R. Weil, +8

Genome biology

Transgenic expression of the deoxynucleotide carrier causes mitochondrial damage that is enhanced by NRTIs for AIDS

William Lewis, Chad P. Haase, Yoon K. Miller, +10

Laboratory Investigation

Mitochondrial DamageMitochondrial FunctionHuman RetrovirusImmunologyTransgenic Expression +6

Direct Amplification, Sequencing and Profiling of Chlamydia trachomatis Strains in Single and Mixed Infection Clinical Samples

Sandeep J. Joseph, Ben Li, Tanvi Ghonasgi, +4

PLoS ONE

EngineeringGeneticsC. Trachomatis GenomeGenomicsHigh Throughput Sequencing +19

Targeted Transgenic Overexpression of Mitochondrial Thymidine Kinase (TK2) Alters Mitochondrial DNA (mtDNA) and Mitochondrial Polypeptide Abundance

Seyed H. Hosseini, James J. Kohler, Chad P. Haase, +10

American Journal Of Pathology

Genome InstabilityMitochondrial Thymidine KinaseMitochondrial FunctionAlters Mitochondrial DnaNatural Sciences +10