Molecular Basis for the Dosing Time-Dependency of Anti-Allodynic Effects of Gabapentin in a Mouse Model of Neuropathic Pain

Abstract

These findings suggest that the dosing time-dependent difference in the anti-allodynic effects of gabapentin is attributable to the circadian oscillation of α2δ-1 subunit expression in the DRG and indicate that the optimizing its dosing schedule helps to achieve rational pharmacotherapy for neuropathic pain.