Concepedia

Time-dependent Dosing

Time-Dependent Dosing is a pharmacological dosing strategy that belongs to the class of dose optimization methods and is distinguished by its explicit incorporation of circadian rhythms or temporal physiological variations to determine the optimal timing and dosage of drug administration for enhancing therapeutic efficacy and minimizing adverse effects.

56

Publications

1.8K

Citations

265

Authors

108

Institutions

Publications per year

2017–2026

6

Parents

Publications

56

Timing optimizes sustained-release indomethacin treatment of osteoarthritis

Françis Lévi, Cathy Le Louarn, Alain Reinberg · Clinical Pharmacology & Therapeutics · 1985 · 110 citations

, , +17

A theoretical analysis of interval drug dosing for cell-cycle-phase-specific drugs

Lutzy Cojocaru, Zvia Agur · Mathematical Biosciences · 1992 · 94 citations

, , +15

Brain-Cocaine Concentrations Determine the Dose Self-Administered by Rats on a Novel Behaviorally Dependent Dosing Schedule

Benjamin Zimmer, Carson V. Dobrin, David C. S. Roberts · Neuropsychopharmacology · 2011 · 92 citations

, , +15

Molecular Basis for the Dosing Time-Dependency of Anti-Allodynic Effects of Gabapentin in a Mouse Model of Neuropathic Pain

Naoki Kusunose, Satoru Koyanagi, Kengo Hamamura et al. · Molecular Pain · 2010 · 78 citations · Full text

, , +17

Anti-inflammatory activity of Aloe vera against a spectrum of irritants

RH Davis, M G Leitner, J M Russo et al. · Journal of the American Podiatric Medical Association · 1989 · 77 citations

, , +15

1–5 of 56

Authors

265

  1. SO
    Shigehiro Ohdo

    Kyushu University, Japan

    9 publications · 319 citations

    9

    h-index

  2. SH
    Shun Higuchi

    Kyushu University, Japan

    6 publications · 209 citations

    6

    h-index

  3. AF
    Akio Fujimura

    Jichi Medical University, Japan

    6 publications · 134 citations

    6

    h-index

  4. SK
    Satoru Koyanagi

    Kyushu University, Japan

    5 publications · 250 citations

    5

    h-index

  5. HT
    Hideto To

    University of Toyama, Japan

    4 publications · 164 citations

    4

    h-index

1–5 of 265

Institutions

108

  1. Kyushu University

    Fukuoka, Japan

    9 h-index

    33 publications

    1.6K citations

  2. Jichi Medical University

    Shimotsuke, Japan

    7 h-index

    23 publications

    503 citations

  3. Hôpital Paul-Brousse

    Villejuif, France

    3 h-index

    11 publications

    362 citations

  4. Inserm

    Paris, France

    2 h-index

    6 publications

    222 citations

  5. Taoka Hospital

    Tokushima, Japan

    2 h-index

    2 publications

    41 citations

  6. University of Toyama

    Toyama, Japan

    2 h-index

    6 publications

    175 citations

  7. Nagasaki University Hospital

    Nagasaki, Japan

    2 h-index

    4 publications

    231 citations

  8. Fondation de Rothschild

    Paris, France

    2 h-index

    4 publications

    342 citations

1–8 of 108

Venues

  1. Chronobiology International

    7 publications · 185 citations

    7

    h-index

  2. PubMed

    Repository · 4 publications · 88 citations

    4

    h-index

  3. 2

    h-index

  4. Antimicrobial Agents and Chemotherapy

    AAC · 2 publications · 40 citations

    2

    h-index

  5. Life Sciences

    2 publications · 26 citations

    2

    h-index

1–5