Pharmacogenetics of Immunosuppressant Polymorphism of CYP3A5 in Renal Transplant Recipients

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

Peter Kuehl, Jiong Zhang, Yvonne Lin et al. · Nature Genetics · 2001 · 2.2K citations

Life Sciences, Genetics, Molecular Biology +17

Human P-glycoprotein transports cyclosporin A and FK506.

Takashi Saeki, Kazumitsu Ueda, Yusuke Tanigawara et al. · Journal of Biological Chemistry · 1993 · 685 citations · Full text

Medicine, Biochemistry, Pharmacology +15

Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus

Dennis A. Hesselink · Clinical Pharmacology & Therapeutics · 2003 · 653 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Tacrolimus pharmacogenetics: polymorphisms associated with expression of cytochrome p4503A5 and p-glycoprotein correlate with dose requirement

Iain MacPhee, Salim Fredericks, Tracy W Tai et al. · Transplantation · 2002 · 314 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Impact of cytochrome P450 3A5 genetic polymorphism on tacrolimus doses and concentration-to-dose ratio in renal transplant recipients1 2

Éric Thervet, Dany Anglicheau, Barry P. King et al. · Transplantation · 2003 · 300 citations

Medicine, Pharmacokinetics, Pharmacology +17