Arbaclofen Placarbil, a Novel R-Baclofen Prodrug: Improved Absorption, Distribution, Metabolism, and Elimination Properties Compared with R-Baclofen

The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation

Andrew P. Halestrap, Nigel T. Price · Biochemical Journal · 1999 · 1.3K citations · Full text

Life Sciences, Biochemistry, Cell Biology +11

Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2.

Rod Humerickhouse, K Lohrbach, Lin Li et al. · PubMed · 2000 · 356 citations

Life Sciences, Biochemistry, Pharmacology +14

Baclofen decreases acid and non‐acid post‐prandial gastro‐oesophageal reflux measured by combined multichannel intraluminal impedance and pH

Marcelo F. Vela, Radu Țuțuian, Philip O. Katz et al. · Alimentary Pharmacology & Therapeutics · 2003 · 319 citations

Medicine, Pharmacology, Pharmacotherapy +16

Antiplatelet Agents Aspirin and Clopidogrel Are Hydrolyzed by Distinct Carboxylesterases, and Clopidogrel Is Transesterificated in the Presence of Ethyl Alcohol

Man Tang, Madhu Mukundan, Jian Yang et al. · Journal of Pharmacology and Experimental Therapeutics · 2006 · 250 citations

Medicine, Biochemistry, Pharmacology +9

Comparison of Intestinal Permeabilities Determined in Multiple in Vitro and inSitu Models: Relationship to Absorption in Humans

Barbra H. Stewart, O. Helen Chan, Rosalind H. Lu et al. · Pharmaceutical Research · 1995 · 186 citations

Pharmacy, Pharmacokinetics, Physiology +12