Concepedia

Pharmacological Characterization of GSK573719 (Umeclidinium): A Novel, Long-Acting, Inhaled Antagonist of the Muscarinic Cholinergic Receptors for Treatment of Pulmonary Diseases

M Salmon, Mark A. Luttmann, James J. Foley, Peter T. Buckley, Dulcie B. Schmidt, Miriam Burman, Edward F. Webb, Christopher J. DeHaas, Charles J. Kotzer, Victoria J. Barrett,

Journal of Pharmacology and Experimental Therapeutics · 2013 · 79 citations · 26 references

DOI

Concepts

References

26

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

, , +14

SOME QUANTITATIVE USES OF DRUG ANTAGONISTS

O. ARUNLAKSHANA, H. O. Schild · British Journal of Pharmacology and Chemotherapy · 1959 · 4K citations · Full text

, , +16

Noninvasive Measurement of Airway Responsiveness in Allergic Mice Using Barometric Plethysmography

Eckard Hamelmann, Jürgen Schwarze, Katsuyuki Takeda et al. · American Journal of Respiratory and Critical Care Medicine · 1997 · 1.3K citations

, , +16

Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters.

J. M. van Rossum · PubMed · 1963 · 1.2K citations

, , +14

Structure and dynamics of the M3 muscarinic acetylcholine receptor

Andrew C. Kruse, Jianxin Hu, Albert C. Pan et al. · Nature · 2012 · 816 citations

, , +12