Concepedia

Publication | Open Access

A Novel Correlation between <i>LINE-1</i> Hypomethylation and the Malignancy of Gastrointestinal Stromal Tumors

DOIFull Paper Access

90

Citations

38

References

2010

Year

Shinichi Igarashi, Hiromu Suzuki, Takeshi Niinuma, Haruo Shimizu, Masanori Nojima, Hiroyuki Iwaki, Takayuki Nobuoka, Toshirou Nishida, Yasuaki Miyazaki, Hiroyuki Takamaru,
Clinical Cancer Research

Abstract

Our data suggest that LINE-1 hypomethylation correlates significantly with the aggressiveness of GISTs and that LINE-1 methylation could be a useful marker for risk assessment. Hypomethylation may increase the malignant potential of GISTs by inducing accumulation of chromosomal aberrations.

References

YearCitations

Page 1