Alzheimer's disease: synapses gone cold

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

Robert D. Terry, Eliezer Masliah, David P. Salmon et al. · Annals of Neurology · 1991 · 4.3K citations

Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

Dominic M. Walsh, Igor Klyubin, Julia V. Fadeeva et al. · Nature · 2002 · 4.2K citations

Synaptic Plasticity, Alzheimer's Disease, Molecular Neuroscience +7

Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis

Rakez Kayed, Elizabeth Head, Jennifer L. Thompson et al. · Science · 2003 · 4K citations

Soluble Amyloid Oligomers, Alzheimer's Disease, Biochemistry +12

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

Ganesh M. Shankar, Shaomin Li, Tapan Mehta et al. · Nature Medicine · 2008 · 3.6K citations · Full text

Amyloid-β Protein Dimers, Neurodegenerative Diseases, Synaptic Plasticity +10

Diffusible, nonfibrillar ligands derived from Aβ _1–42 are potent central nervous system neurotoxins

Mary P. Lambert, Avlin Barlow, Brett A. Chromy et al. · Proceedings of the National Academy of Sciences · 1998 · 3.5K citations · Full text