Drug‐Free Macromolecular Therapeutics: Induction of Apoptosis by Coiled‐Coil‐Mediated Cross‐Linking of Antigens on the Cell Surface

Abstract

Peptide biorecognition: The heterodimerization of complementary randomly coiled peptides, one (red) bound to an antibody fragment (gray) and one (green) grafted to a copolymer (black), to form coiled coils resulted in the cross-linking of CD20 target antigens (orange) on Raji B cells and consequently the initiation of apoptosis (see schematic representation). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.