The Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Cross-Talk with Hepatic Nuclear Factor 4α to Synergistically Activate the Human CYP2C9 Promoter

Resampling-Based Multiple Testing: Examples and Methods for p-Value Adjustment.

Michael A. Martin, Peter H. Westfall, S. Stanley Young · Biometrics · 1994 · 1.7K citations

Public Health, Biostatistics, Experimental Design +11

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

Steven A. Kliewer, John T. Moore, Laura Wade et al. · Cell · 1998 · 1.5K citations · Full text

Life Sciences, Biochemistry, Endocrinology +16

Hepatocyte Nuclear Factor 4α (Nuclear Receptor 2A1) Is Essential for Maintenance of Hepatic Gene Expression and Lipid Homeostasis

Graham P. Hayhurst, Ying‐Hue Lee, Gilles Lambert et al. · Molecular and Cellular Biology · 2001 · 1.1K citations · Full text

Medicine, Developmental Biology, Molecular Genetics +9

The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of<i>CYP3A4</i>by Rifampicin through a Distal Enhancer Module

Bryan Goodwin, Ecushla Hodgson, Christopher Liddle · Molecular Pharmacology · 1999 · 643 citations

Medicine, Molecular Biology, Pharmacology +17

The role of the CFP2C9-Leu 359 allelic variant in the tolbutamide polymorphism

Theresa H. Sullivan-Klose, Burhan I. Ghanayem, Douglas A. Bell et al. · Pharmacogenetics · 1996 · 587 citations

Medicine, Genetics, Pharmacology +17