Expression of functional tissue factor by neutrophil extracellular traps in culprit artery of acute myocardial infarction

Abstract

The interaction of thrombin-activated platelets with PMNs at the site of plaque rupture during acute STEMI results in local NET formation and delivery of active TF. The notion that NETs represent a mechanism by which PMNs release thrombogenic signals during atherothrombosis may offer novel therapeutic targets.