β-Substituted cyclohexanecarboxamide cathepsin K inhibitors: Modification of the 1,2-disubstituted aromatic core

Cathepsin K, but Not Cathepsins B, L, or S, Is Abundantly Expressed in Human Osteoclasts

Fred H. Drake, Robert A. Dodds, Ian E. James et al. · Journal of Biological Chemistry · 1996 · 716 citations · Full text

Medicine, Biochemistry, Molecular Biology +11

Proteolytic Activity of Human Osteoclast Cathepsin K

Mary J. Bossard, Thaddeus A. Tomaszek, Scott K. Thompson et al. · Journal of Biological Chemistry · 1996 · 491 citations · Full text

Medicine, Biochemistry, Bone Metabolism +11

Human Cathepsin O2, a Matrix Protein-degrading Cysteine Protease Expressed in Osteoclasts

Dieter Brömme, Kathleen Okamoto, Bruce B. Wang et al. · Journal of Biological Chemistry · 1996 · 425 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Molecular cloning of a possible cysteine proteinase predominantly expressed in osteoclasts.

K. Tezuka, Y. Tezuka, Atsushi Maejima et al. · Journal of Biological Chemistry · 1994 · 339 citations · Full text

Medicine, Cell Biology, Molecular Biology +14

Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K

W. Cameron Black, Christopher I. Bayly, Dana Davis et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 140 citations

Life Sciences, Chemistry, Medicinal Chemistry +14