Concepedia

Efficient Screening of Cytochrome P450 BM3 Mutants for Their Metabolic Activity and Diversity toward a Wide Set of Drug-Like Molecules in Chemical Space

Jelle Reinen, Jolanda van Leeuwen, Yongmin Li, Lifang Sun, Peter D. J. Grootenhuis, Caroline J. Decker, John Saunders, Nico Vermeulen, Jan N. M. Commandeur

Drug Metabolism and Disposition · 2011 · 44 citations · 31 references

DOI

Concepts

References

31

Characterization of a catalytically self-sufficient 119,000-dalton cytochrome P-450 monooxygenase induced by barbiturates in Bacillus megaterium.

Linda O. Narhi, Armand J. Fulco · Journal of Biological Chemistry · 1986 · 628 citations · Full text

, , +16

The structure of the cytochrome p450BM-3 haem domain complexed with the fatty acid substrate, palmitoleic acid

Huiying Li, T.L. Poulos · Nature Structural Biology · 1997 · 466 citations

, , +16

Regio- and Enantioselective Alkane Hydroxylation with Engineered Cytochromes P450 BM-3

Matthew W. Peters, Peter Meinhold, Anton Glieder et al. · Journal of the American Chemical Society · 2003 · 333 citations

, , +17

Protein engineering of <i>Bacillus megaterium</i> CYP102

Angus B. Carmichael, Luet‐Lok Wong · European Journal of Biochemistry · 2001 · 246 citations

, , +17

Engineered Alkane‐Hydroxylating Cytochrome P450<sub>BM3</sub> Exhibiting Nativelike Catalytic Properties

Rudi Fasan, Mike M. Chen, Nathan Crook et al. · Angewandte Chemie International Edition · 2007 · 240 citations

, , +15