Concepedia

Discovery and optimization of pyridazinone non-nucleoside inhibitors of HIV-1 reverse transcriptase

Zachary K. Sweeney, James P. Dunn, Yu Li, Gabrielle Heilek, Pete Dunten, Todd R. Elworthy, Xiaochun Han, Seth F. Harris, Donald R. Hirschfeld, J. Heather Hogg,

Bioorganic & Medicinal Chemistry Letters · 2008 · 42 citations · 10 references

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Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 Variants

Kalyan Das, Arthur D. Clark, Paul Lewi et al. · Journal of Medicinal Chemistry · 2004 · 511 citations

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High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations

Kalyan Das, Joseph D. Bauman, Arthur D. Clark et al. · Proceedings of the National Academy of Sciences · 2008 · 337 citations · Full text

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Resistance profile and cross‐resistance of HIV‐1 among patients failing a non‐nucleoside reverse transcriptase inhibitor‐containing regimen*

Constance Delaugerre, Raymond Rohban, Anne Simon et al. · Journal of Medical Virology · 2001 · 126 citations

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Delavirdine Susceptibilities and Associated Reverse Transcriptase Mutations in Human Immunodeficiency Virus Type 1 Isolates from Patients in a Phase I/II Trial of Delavirdine Monotherapy (ACTG 260)

Lisa M. Demeter, Robert W. Shafer, Patricia M. Meehan et al. · Antimicrobial Agents and Chemotherapy · 2000 · 88 citations

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Inhibitor binding alters the directions of domain motions in HIV‐1 reverse transcriptase

Nuri A. Temiz, İvet Bahar · Proteins Structure Function and Bioinformatics · 2002 · 80 citations

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