Crossing the Species Barrier by PrPSc Replication In Vitro Generates Unique Infectious Prions

A new variant of Creutzfeldt-Jakob disease in the UK

Robert Will, James W. Ironside, Martin Zeidler et al. · The Lancet · 1996 · 2.7K citations

Medicine, Molecular Genetics, Neurology +8

Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD

John Collinge, Katie Sidle, Julie Meads et al. · Nature · 1996 · 1.7K citations

Veterinary Medicine, Genetics, Molecular Genetics +15

Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding

Gabriela P. Saborı́o, Bruno Permanne, Claudio Soto · Nature · 2001 · 1.3K citations

Veterinary Medicine, Biochemistry, Molecular Biology +15

Eight prion strains have PrPSc molecules with different conformations

Jiri Safar, Holger Wille, Vincenza Itri et al. · Nature Medicine · 1998 · 1.2K citations

Life Sciences, Biochemistry, Molecular Biology +14

In Vitro Generation of Infectious Scrapie Prions

Joaquı́n Castilla, Paula Saá, Claudio Hetz et al. · Cell · 2005 · 784 citations · Full text

Veterinary Medicine, Biology, Microbiology +14