Cell-Based High-Throughput Screening Assay System for Monitoring G Protein-Coupled Receptor Activation Using β-Galactosidase Enzyme Complementation Technology

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

Ji-Hu Zhang, Thomas D.Y. Chung, Kevin R. Oldenburg · SLAS DISCOVERY · 1999 · 7K citations · Full text

Pharmacy, Medicinal Chemistry, Drug Design +16

β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function

Martin J. Lohse, Jeffrey Benovic, Juan Codina et al. · Science · 1990 · 1.2K citations

Life Sciences, Biochemistry, Molecular Biology +14

Role of β-Arrestin in Mediating Agonist-Promoted G Protein-Coupled Receptor Internalization

Stephen S. G. Ferguson, William E. Downey, Anne-Marie Colapietro et al. · Science · 1996 · 964 citations

Medicine, Pharmacology, Cell Signaling +16

Phosphodiesterase activation by photoexcited rhodopsin is quenched when rhodopsin is phosphorylated and binds the intrinsic 48-kDa protein of rod outer segments.

Ursula Wilden, S W Hall, H. Kühn · Proceedings of the National Academy of Sciences · 1986 · 793 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Detection of β ₂ -adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET)

Stéphane Angers, Ali Salahpour, Éric Joly et al. · Proceedings of the National Academy of Sciences · 2000 · 631 citations

Life Sciences, Biochemistry, Molecular Biology +17