Concepedia

Behavior of Monoclonal Antibodies: Relation Between the Second Virial Coefficient (B 2) at Low Concentrations and Aggregation Propensity and Viscosity at High Concentrations

Shuntaro Saito, Jun Hasegawa, Naoki Kobayashi, Naoyuki Kishi, Susumu Uchiyama, Kiichi Fukui

Pharmaceutical Research · 2011 · 152 citations · 37 references

DOI

Concepts

References

37

Analytical ultracentrifugation in biochemistry and polymer science

Analytica Chimica Acta · 1995 · 2K citations

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Challenges in the development of high protein concentration formulations

Zahra Shahrokh, Jun 军 Liu 刘 · Journal of Pharmaceutical Sciences · 2004 · 879 citations

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Monoclonal antibody successes in the clinic

Janice M. Reichert, Clark Rosensweig, Laura Faden et al. · Nature Biotechnology · 2005 · 727 citations

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Reversible Self-Association Increases the Viscosity of a Concentrated Monoclonal Antibody in Aqueous Solution

Jun Liu, Mary D.H. Nguyen, James D. Andya et al. · Journal of Pharmaceutical Sciences · 2005 · 439 citations

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Strategies for the Assessment of Protein Aggregates in Pharmaceutical Biotech Product Development

John den Engelsman, Patrick Garidel, Ronald Smulders et al. · Pharmaceutical Research · 2010 · 350 citations · Full text

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