Concepedia

Monoclonal antibody successes in the clinic

Janice M. Reichert, Clark Rosensweig, Laura Faden, Matthew C. Dewitz

Nature Biotechnology · 2005 · 727 citations · 7 references

DOI

Concepts

References

7

Continuous cultures of fused cells secreting antibody of predefined specificity

Georges Köhler, César Milstein · Nature · 1975 · 17.2K citations

, , +11

Replacing the complementarity-determining regions in a human antibody with those from a mouse

Peter Jones, Paul H. Dear, Jefferson Foote et al. · Nature · 1986 · 1.4K citations

, , +13

Chimeric human antibody molecules: mouse antigen-binding domains with human constant region domains.

Sherie L. Morrison, M J Johnson, L A Herzenberg et al. · Proceedings of the National Academy of Sciences · 1984 · 1K citations · Full text

, , +17

Production of functional chimaeric mouse/human antibody

Gabrielle L. Boulianne, Nobumichi Hozumi, Marc J. Shulman · Nature · 1984 · 543 citations

, , +12

The hybridoma revolution: an offshoot of basic research

Cèsar Milstein · BioEssays · 1999 · 95 citations

, , +14